Search Ontology:
GO: Molecular Function

histone deacetylase activity, NAD-dependent

Term ID
GO:0017136
Synonyms
  • histone deacetylase activity
  • NAD-dependent histone deacetylase activity
  • NAD-dependent histone lysine deacetylase activity
  • SIR2
  • sirtuin
Definition
Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide. (2)
References
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
has subtype
Phenotype
Phenotype caused by Genes
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