fatty acid elongase activity

Term ID

GO:0009922

Synonyms

• condensing enzyme
• elongation of very long chain fatty acids activity
• ELOVL
• very-long-chain 3-ketoacyl-CoA synthase
• very-long-chain 3-oxoacyl-CoA synthase
• very-long-chain beta-ketoacyl-CoA synthase

Definition

Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. (2)

References

• EC:2.3.1.199
• MetaCyc:RXN-7697
• RHEA:32727
• Reactome:R-HSA-2046083
• Reactome:R-HSA-2046088
• Reactome:R-HSA-2046090
• Reactome:R-HSA-2046094
• Reactome:R-HSA-2046095
• Reactome:R-HSA-2046100
• Reactome:R-HSA-548800
• Reactome:R-HSA-548814
• Reactome:R-HSA-548815
• Reactome:R-HSA-548830

Ontology

GO: Molecular Function    QuickGO    AmiGO