cohesin complex

Term ID

GO:0008278

Synonyms

• 14S cohesin
• 9S cohesin
• cohesin core heterodimer
• nuclear cohesin complex
• SMC complex
• SMC/kleisin ring complex
• Smc1-Smc3 complex

Definition

A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 9887095

References

Ontology

GO: Cellular Component    QuickGO    AmiGO