phospholipase C-activating G protein-coupled receptor signaling pathway

Term ID

GO:0007200

Synonyms

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
G protein signaling, coupled to IP3 second messenger (phospholipase C activating)
G protein signalling, coupled to IP3 second messenger (phospholipase C activating)
G-protein coupled receptor signaling pathway coupled to IP3 second messenger
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)
phospholipase C-activating G-protein coupled receptor signaling pathway
PLC-activating GPCR signaling pathway
protein kinase C-activating G protein-coupled receptor signaling pathway

Definition

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. 0815316194

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway Show first 5 Terms
has subtype: phospholipase C-activating adrenergic receptor signaling pathway phospholipase C-activating angiotensin-activated signaling pathway phospholipase C-activating dopamine receptor signaling pathway phospholipase C-activating endothelin receptor signaling pathway phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway ... Show All 9 Terms

phospholipase C-activating adrenergic receptor signaling pathway phospholipase C-activating angiotensin-activated signaling pathway phospholipase C-activating dopamine receptor signaling pathway phospholipase C-activating endothelin receptor signaling pathway phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway phospholipase C-activating G protein-coupled glutamate receptor signaling pathway phospholipase C-activating opsin-mediated signaling pathway phospholipase C-activating serotonin receptor signaling pathway phospholipase C-activating tachykinin receptor signaling pathway Show first 5 Terms
has_part: phospholipase C activator activity

phospholipase C activator activity Show first 5 Terms
negatively regulated by: negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Show first 5 Terms
positively regulated by: positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Show first 5 Terms
regulated by: regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Show first 5 Terms

Phenotype

Phenotype caused by Genes