7-methylguanosine mRNA capping

Term ID

GO:0006370

Synonyms

• 5' end capping
• 5' mRNA capping
• 5'-end mRNA processing
• 5'-end processing
• mRNA capping

Definition

The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively. 9266685

References

• Reactome:R-HSA-72086

Ontology

GO: Biological Process    QuickGO    AmiGO