double-strand break repair via nonhomologous end joining

Term ID

GO:0006303

Synonyms

NHEJ

Definition

The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. (2)

References

Reactome:R-HSA-5693571

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: gap filling involved in double-strand break repair via nonhomologous end joining

gap filling involved in double-strand break repair via nonhomologous end joining Show first 5 Terms
is a type of: double-strand break repair

double-strand break repair Show first 5 Terms
has subtype: double-strand break repair via alternative nonhomologous end joining double-strand break repair via classical nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining double-strand break repair via classical nonhomologous end joining Show first 5 Terms
negatively regulated by: negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of double-strand break repair via nonhomologous end joining Show first 5 Terms
positively regulated by: positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair via nonhomologous end joining Show first 5 Terms
regulated by: regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining Show first 5 Terms

Phenotype

Phenotype caused by Genes