DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Term ID

GO:0003918

Synonyms

deoxyribonucleate topoisomerase
deoxyribonucleic topoisomerase activity
DNA gyrase activity
DNA topoisomerase (ATP-hydrolysing)
DNA topoisomerase II
DNA topoisomerase II activity
DNA topoisomerase IV activity
DNA topoisomerase type II activity
DNA-gyrase activity
topoisomerase
topoisomerase II
type II DNA topoisomerase activity

Definition

Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. 8811192

References

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: ATP-dependent activity, acting on DNA DNA topoisomerase activity

ATP-dependent activity, acting on DNA DNA topoisomerase activity Show first 5 Terms
has subtype: DNA negative supercoiling activity

DNA negative supercoiling activity Show first 5 Terms
negatively regulated by: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity Show first 5 Terms
positively regulated by: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Show first 5 Terms
regulated by: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity Show first 5 Terms

Phenotype

Phenotype caused by Genes