antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Term ID

GO:0002479

Synonyms

• cross presentation
• cross-presentation
• exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent
• TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I
• TAP-dependent exogenous peptide antigen processing and presentation via MHC class I

Definition

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules. (3)

References

• Reactome:R-HSA-1236973
• Reactome:R-HSA-1236974
• Reactome:R-HSA-1236978

Ontology

GO: Biological Process    QuickGO    AmiGO