marginal zone B cell differentiation

Term ID

GO:0002315

Synonyms

• marginal zone B cell development
• marginal zone B lymphocyte differentiation
• marginal zone B-cell differentiation
• marginal zone B-lymphocyte differentiation

Definition

The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). 0781735149

References

Ontology

GO: Biological Process    QuickGO    AmiGO