Prp19 complex

Term ID

GO:0000974

Synonyms

• MOS4-Associated Complex
• nineteen complex
• NTC
• Prp19/CDC5 complex

Definition

A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO