Search Ontology:
GO: Molecular Function

first spliceosomal transesterification activity

Term ID
GO:0000384
Synonyms
  • lariat formation, 5'-splice site cleavage
Definition
Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. (2)
References
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is part of
is a type of
Phenotype
Phenotype caused by Genes
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