nuclear exosome (RNase complex)

Term ID

GO:0000176

Synonyms

• eukaryotic exosome multienzyme ribonuclease complex
• nuclear exosome (ribonuclease complex)
• nuclear exosome multienzyme ribonuclease complex

Definition

A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. (3)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO