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Human Disease

Lewy body dementia

Term ID
DOID:12217
Synonyms
  • Dementia with Lewy bodies
  • Diffuse Lewy body disease
  • Lewy body disease
  • Senile dementia of the Lewy body type
Definition
A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies. (2)
References
  • GARD:3243
  • ICD10CM:G31.83
  • ICD9CM:331.82
  • MESH:D020961
  • MIM:127750
  • NCI:C84826
  • SNOMEDCT_US_2023_03_01:192808003
  • UMLS_CUI:C0752347
Ontology
Human Disease   ( DOID:12217 )
Relationships
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Genes Involved
Zebrafish Models