Lewy body dementia

Term ID

DOID:12217

Synonyms

• Dementia with Lewy bodies
• Diffuse Lewy body disease
• Lewy body disease
• Senile dementia of the Lewy body type

Definition

A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies. (2)

References

• GARD:3243
• ICD10CM:G31.83
• ICD9CM:331.82
• MESH:D020961
• MIM:127750
• NCI:C84826
• SNOMEDCT_US_2023_03_01:192808003
• UMLS_CUI:C0752347

Ontology

Human Disease   ( DOID:12217 )