tris

Term ID

CHEBI:9754

Synonyms

1,1,1-tris(hydroxymethyl)methanamine
2-Amino-2-(hydroxymethyl)-1,3-propanediol
2-amino-2-(hydroxymethyl)propane-1,3-diol
aminotris(hydroxymethyl)methane
THAM
Tris
Tris amino
Tris base
Tris buffer
tris(hydroxymethyl)aminomethane
Tris-base
Trizma
Trometamol
Tromethamine

Definition

A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC.

References

Beilstein:741883
CAS:77-86-1
DrugBank:DB03754
Drug_Central:2771
Gmelin:217857
KEGG:C07182
KEGG:D00396
PDBeChem:TRS
PMID:22553829
Reaxys:741883
Wikipedia:Tris

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: primary amino compound triol

primary amino compound triol Show first 5 Terms
has_role: buffer

buffer Show first 5 Terms
inverse has_functional_parent: bis-tris bis-tris propane N-tris(hydroxymethyl)methylglycine TES

bis-tris bis-tris propane N-tris(hydroxymethyl)methylglycine TES Show first 5 Terms
inverse is_conjugate_acid_of: Htris

Htris Show first 5 Terms
is_conjugate_base_of: Htris

Htris Show first 5 Terms

Phenotype

Phenotype resulting from tris

Phenotype where environments contain tris

Phenotype modified by environments containing tris

Human Disease / Model Data