Search Ontology:
ChEBI

sapanisertib

Term ID
CHEBI:91450
Synonyms
  • 3-(2-amino-1,3-benzoxazol-5-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine
  • CB-228
  • FTH-003
  • INK 128
  • INK-128
  • INK128
  • MLN 0128
  • MLN-0128
  • MLN0128
  • sapanisertib
  • sapanisertibum
  • TAK 228
  • TAK-228
  • TAK228
Definition
A 1,3-benzoxazole substituted by amino and 4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl groups at positions 2 and 5, respectively. It is a ATP-competitive inhibitor of mTORC1 and mTORC2 that exhibits antineoplastic activity.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from sapanisertib
Phenotype where environments contain sapanisertib
Phenotype modified by environments containing sapanisertib
Human Disease Model
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