PF-00477736

Term ID

CHEBI:91385

Synonyms

(2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-4H-[1,2]diazepino[4,5,6-cd]indol-8-yl]acetamide
PF 477736
PF-477736

Definition

A diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: amino acid amide diazepinoindole pyrazoles

amino acid amide diazepinoindole pyrazoles Show first 5 Terms
has_role: antineoplastic agent EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor

antineoplastic agent EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from PF-00477736

Phenotype where environments contain PF-00477736

Phenotype modified by environments containing PF-00477736

Human Disease / Model Data