CD437

Term ID

CHEBI:88334

Synonyms

6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid
6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]-2-naphthalenecarboxylic acid
6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
AHPN
Apoptosis Activator VI
Cd 437
CD-437

Definition

A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)gamma and induces cell cycle arrest and apoptosis in various cancer cells.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: adamantanes monocarboxylic acid naphthoic acid phenols

adamantanes monocarboxylic acid naphthoic acid phenols Show first 5 Terms
has_role: apoptosis inducer retinoic acid receptor gamma agonist

apoptosis inducer retinoic acid receptor gamma agonist Show first 5 Terms
inverse has_functional_parent: adapalene

adapalene Show first 5 Terms

Phenotype

Phenotype resulting from CD437

Phenotype where environments contain CD437

Phenotype modified by environments containing CD437

Human Disease Model