palbociclib

Term ID

CHEBI:85993

Synonyms

6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
IBRANCE
palbociclib
PD 0332991
PD 332991
PD-0332991
PD0332991
UNII-G9ZF61LE7G

Definition

A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyridine aromatic ketone cyclopentanes piperidines pyridopyrimidine ... Show All 7 Terms

aminopyridine aromatic ketone cyclopentanes piperidines pyridopyrimidine secondary amino compound tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent EC 2.7.11.22 (cyclin-dependent kinase) inhibitor

antineoplastic agent EC 2.7.11.22 (cyclin-dependent kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from palbociclib

Phenotype where environments contain palbociclib

Phenotype modified by environments containing palbociclib

Human Disease Model