Search Ontology:
ChEBI
Src Inhibitor-1
- Term ID
- CHEBI:78332
- Synonyms
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- (4'-oxyphenyl-phenylamino)-6,7-dimethoxyquinazoline
- 4-(4'-phenoxyanilino)-6,7-dimethoxyquinazoline
- 6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
- 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
- SKI-1
- Src kinase inhibitor I
- Src-l1
- Definition
- A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases.
- References
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- LINCS:LSM-3112
- PMID:17850214
- Reaxys:8790191
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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Phenotype
Phenotype resulting from Src Inhibitor-1
Phenotype where environments contain Src Inhibitor-1
Phenotype modified by environments containing Src Inhibitor-1
Human Disease / Model Data