Search Ontology:
ChEBI
tilidine
- Term ID
- CHEBI:77823
- Synonyms
-
- ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
- rac-ethyl (1R,2S)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
- rac-ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
- tilidina
- tilidine
- tilidinum
- Definition
- A racemate that is an equimolar mixture of the two trans diastereoisomers of ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, namely dextilidine and ent-dextilidine. It is used (commonly as the hydrochloride hemihydrate) as an opioid analgesic for the management of moderate to severe pain. A prodrug, it is metabolised in the body to nortilidine, which is responsible for the analgesic activity; virtually all of the opioid activity resides in the (1S,2R) isomer.
- References
-
- CAS:51931-66-9
- KEGG:D08597
- PMID:11144998
- PMID:21140136
- PMID:212687
- PMID:22381043
- PMID:23844964
- PMID:2610722
- PMID:3803198
- PMID:6852098
- PMID:720208
- Patent:GB1120186
- Patent:US3557127
- Reaxys:2813935
- Wikipedia:Tilidine
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_part
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- has_role
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Phenotype
Phenotype resulting from tilidine
Phenotype where environments contain tilidine
Phenotype modified by environments containing tilidine
Human Disease Model