Search Ontology:
ChEBI
dexverapamil
- Term ID
- CHEBI:77734
- Synonyms
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- (+)-(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
- (+)-(R)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
- (+)-(R)-verapamil
- (+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
- (+)-3-(3,4-dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
- (+)-verapamil
- (2R)-(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
- (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
- (R)-(+)-verapamil
- (R)-verapamil
- dexverapamil
- dexverapamilo
- dexverapamilum
- Definition
- A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
- References
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- CAS:38321-02-7
- PMID:7636539
- PMID:8698736
- PMID:8698738
- PMID:8698739
- PMID:8698740
- PMID:8712693
- Reaxys:3657914
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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- inverse has_part
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- inverse is_conjugate_acid_of
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- inverse is_enantiomer_of
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- is_conjugate_base_of
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- is_enantiomer_of
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Show first 5 Terms
Phenotype
Phenotype resulting from dexverapamil
Phenotype where environments contain dexverapamil
Phenotype modified by environments containing dexverapamil
Human Disease Model