Search Ontology:
ChEBI

proglumetacin

Term ID
CHEBI:76263
Synonyms
  • 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate
  • proglumetacin
  • proglumetacina
  • proglumetacine
  • proglumetacinum
Definition
A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_functional_parent
has_role
inverse has_part
Phenotype
Phenotype resulting from proglumetacin
Phenotype where environments contain proglumetacin
Phenotype modified by environments containing proglumetacin
Human Disease Model
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