temozolomide

Term ID

CHEBI:72564

Synonyms

• 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
• 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
• 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
• 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
• 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
• BRN 5547136
• CCRG 81045
• CCRG-81045
• CCRIS 8996
• M & B 39831
• M&B 39831
• MB 39831
• methazolastone
• NSC 362856
• Sch 52365
• Temodal
• Temodar
• temozolomida
• temozolomide
• temozolomidum
• TMZ

Definition

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

References

• CAS:85622-93-1
• DrugBank:DB00853
• Drug_Central:2589
• HMDB:HMDB0014991
• KEGG:D06067
• LINCS:LSM-4590
• PMID:22680781
• PMID:22818211
• PMID:23246370
• PMID:23254891
• PMID:23293540
• PMID:23335050
• PMID:23362460
• PMID:23377829
• PMID:23385995
• PMID:23389760
• Patent:DE3231255
• Reaxys:5547136
• Wikipedia:Temozolomide

Ontology

ChEBI  ( EBI )

Resources

CTD