Search Ontology:
ChEBI
methyl 5-aminolevulinate
- Term ID
- CHEBI:724125
- Synonyms
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- 5-aminolevulinic acid methyl ester
- aminolevulinic acid methyl ester
- methyl 5-amino-4-oxopentanoate
- Methyl aminolevulinate
- methyl delta-aminolevulinate
- Definition
- The methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells.
- References
-
- CAS:33320-16-0
- DrugBank:DB00992
- Drug_Central:168
- KEGG:D08204
- PMID:21197524
- PMID:21254852
- PMID:21978711
- PMID:22582911
- PMID:22785615
- PMID:22949035
- PMID:22971196
- PMID:23046014
- PMID:23212624
- Reaxys:5921212
- Wikipedia:Methyl_Aminolevulinate
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_functional_parent
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- has_role
-
- inverse has_part
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Phenotype
Phenotype resulting from methyl 5-aminolevulinate
Phenotype where environments contain methyl 5-aminolevulinate
Phenotype modified by environments containing methyl 5-aminolevulinate
Human Disease Model