bedaquiline fumarate

Term ID

CHEBI:72295

Synonyms

(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenylbutan-2-ol bis[(2Z)-but-2-enedioate]
6-bromo-3-[(1R,2S)-4-(dimethylammonio)-2-hydroxy-2-(1-naphthyl)-1-phenylbutyl]-2-methoxyquinolinium (2E)-but-2-enedioate
R403323
Sirturo

Definition

A fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid. It is used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria.

References

CAS:845533-86-0
DrugBank:DBSALT000016
KEGG:D09873
Patent:WO2008068231
Reaxys:18368422

Ontology

ChEBI ( EBI )

Relationships

is a type of: fumarate salt

fumarate salt Show first 5 Terms
has_part: bedaquiline(2+)

bedaquiline(2+) Show first 5 Terms
has_role: antitubercular agent ATP synthase inhibitor

antitubercular agent ATP synthase inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from bedaquiline fumarate

Phenotype where environments contain bedaquiline fumarate

Phenotype modified by environments containing bedaquiline fumarate

Human Disease / Model Data