procarbazine

Term ID

CHEBI:71417

Synonyms

• 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
• 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine
• 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
• N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide
• N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
• N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine
• N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide
• N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
• N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide
• p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide
• Procarbazin
• procarbazina
• procarbazine
• procarbazinum

Definition

A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.

References

• CAS:671-16-9
• DrugBank:DB01168
• Drug_Central:2272
• HMDB:HMDB0015299
• KEGG:C07402
• KEGG:D08423
• LINCS:LSM-2272
• PMID:21420247
• PMID:21703849
• PMID:21740300
• PMID:21870118
• PMID:22423248
• PMID:22708037
• PMID:22744756
• PMID:22851558
• PMID:22913972
• PMID:23071237
• Patent:BE618638
• Patent:US2007122414
• Patent:US2008107661
• Patent:US3520926
• Patent:US3830840
• Reaxys:958270
• Wikipedia:Procarbazine

Ontology

ChEBI  ( EBI )

Resources

CTD