Search Ontology:
ChEBI

clofarabine

Term ID
CHEBI:681569
Synonyms
  • (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
  • CAFdA
  • Cl-F-Ara-A
  • clofarabina
  • clofarabine
  • clofarabinum
Definition
A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from clofarabine
Phenotype where environments contain clofarabine
Phenotype modified by environments containing clofarabine
Human Disease / Model Data
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