Search Ontology:
ChEBI
TMC-52D
- Term ID
- CHEBI:66241
- Synonyms
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- (2R*,3R*)-3-{[(2S)-1-({4-[(3-aminopropyl)amino]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}oxirane-2-carboxylic acid
- Definition
- An epoxide which is a carboxamide obtained by the formal condensation of one of the carboxy groups of oxirane-2,3-dicarboxylic acid with N-{4-[(3-aminopropyl)amino]butyl}-L-phenylalaninamide. It is a natural product, isolated from Gliocladium sp. F-2665. TMC-52D acts as an inhibitor of cysteine proteinases, particularly cathepsin B (EC 3.4.22.1), cathepsin L (EC 3.4.22.15), and papain (EC 3.4.22.2), with IC50 values of 280 nM, 6 nM, and 49 nM, respectively. The epoxide group has trans configuration but its exact stereochemistry is uncertain: it is either (2R,3R) or (2S,3S).
- References
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- PMID:9727388
- Reaxys:8169487
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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Phenotype
Phenotype resulting from TMC-52D
Phenotype where environments contain TMC-52D
Phenotype modified by environments containing TMC-52D
Human Disease Model