ximelagatran

Term ID

CHEBI:65172

Synonyms

ethyl 2-[[(1R)-1-cyclohexyl-2- [(2S)-2-[[4-(N'-hydroxycarbamimidoyl) phenyl]methylcarbamoyl]azetidin-1-yl]- 2-oxo-ethyl]amino]acetate
ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate
Exanta
Exarta
H 376-95
H 376/95
H 37695
ximelagatran
ximelagatran (oxime form)
ximelagatranum

Definition

A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted into the corresponding amidoxime. A prodrug for melagatran, ximelagatran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: amidoxime azetidines carboxamide ethyl ester secondary amino compound ... Show All 7 Terms

amidoxime azetidines carboxamide ethyl ester secondary amino compound secondary carboxamide tertiary carboxamide Show first 5 Terms
has_functional_parent: melagatran

melagatran Show first 5 Terms
has_role: anticoagulant EC 3.4.21.5 (thrombin) inhibitor prodrug serine protease inhibitor

anticoagulant EC 3.4.21.5 (thrombin) inhibitor prodrug serine protease inhibitor Show first 5 Terms
inverse is_tautomer_of: ximelagatran (hydroxylamine form)

ximelagatran (hydroxylamine form) Show first 5 Terms
is_tautomer_of: ximelagatran (hydroxylamine form)

ximelagatran (hydroxylamine form) Show first 5 Terms

Phenotype

Phenotype resulting from ximelagatran

Phenotype where environments contain ximelagatran

Phenotype modified by environments containing ximelagatran

Human Disease Model