leuprolide

Term ID

CHEBI:6427

Synonyms

• (D-Leu(6),des-Gly-NH2(10),Pro-ethylamide(9))-gonadotropin-releasing hormone
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
• Leuprorelin
• leuprorelina
• leuproreline
• leuprorelinum
• pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5
• pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

Definition

An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

References

• CAS:53714-56-0
• DrugBank:DB00007
• Drug_Central:1559
• KEGG:C07612
• KEGG:D08113
• Patent:DE2446005
• Patent:US4005063
• Reaxys:741818

Ontology

ChEBI  ( EBI )

Resources

CTD