methiothepin

Term ID

CHEBI:64203

Synonyms

• (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
• (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin
• (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin
• 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
• 1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine
• 1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine
• Methiothepine
• metitepina
• metitepine
• metitepinum

Definition

A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

References

• CAS:20229-30-5
• HMDB:HMDB0254534
• LINCS:LSM-4320
• PMID:18033297
• PMID:18996971
• PMID:19837141
• PMID:19995401
• PMID:20171242
• PMID:20233210
• PMID:20331882
• PMID:20547148
• PMID:21062995
• PMID:21403818
• PMID:21514998
• PMID:21964383
• Patent:NL6608618
• Patent:US3379729
• Patent:US4444778
• Patent:US6331536
• Reaxys:626221
• Wikipedia:Metitepine

Ontology

ChEBI  ( EBI )

Resources

CTD