vanoxerine dihydrochloride

Term ID

CHEBI:64086

Synonyms

1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride
1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazinediium dichloride
GBR 12909 dihydrochloride
GBR12909 dihydrochloride
Vanoxerine hydrochloride

Definition

A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: vanoxerine(2+)

vanoxerine(2+) Show first 5 Terms
has_role: dopamine uptake inhibitor

dopamine uptake inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from vanoxerine dihydrochloride

Phenotype where environments contain vanoxerine dihydrochloride

Phenotype modified by environments containing vanoxerine dihydrochloride

Human Disease Model