CGP 78608 hydrochloride

Term ID

CHEBI:64065

Synonyms

(1S)-N-[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]-1-phosphonoethanaminium chloride
[(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid hydrochloride

Definition

A hydrochloride that is the monohydrochloride salt of CGP 78608. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_role: anticonvulsant NMDA receptor antagonist prodrug

anticonvulsant NMDA receptor antagonist prodrug Show first 5 Terms
inverse is_conjugate_acid_of: CGP 78608(1+)

CGP 78608(1+) Show first 5 Terms
is_conjugate_base_of: CGP 78608(1+)

CGP 78608(1+) Show first 5 Terms

Phenotype

Phenotype resulting from CGP 78608 hydrochloride

Phenotype where environments contain CGP 78608 hydrochloride

Phenotype modified by environments containing CGP 78608 hydrochloride

Human Disease Model