CGP 78608 hydrochloride

Term ID

CHEBI:64065

Synonyms

(1S)-N-[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]-1-phosphonoethanaminium chloride
[(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid hydrochloride

Definition

A hydrochloride that is the monohydrochloride salt of CGP 78608. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_role: anticonvulsant NMDA receptor antagonist prodrug

anticonvulsant NMDA receptor antagonist prodrug Show first 5 Terms
inverse is_conjugate_acid_of: CGP 78608(1+)

CGP 78608(1+) Show first 5 Terms
is_conjugate_base_of: CGP 78608(1+)

CGP 78608(1+) Show first 5 Terms

Phenotype

Phenotype resulting from CGP 78608 hydrochloride

Phenotype where environments contain CGP 78608 hydrochloride

Phenotype modified by environments containing CGP 78608 hydrochloride

Phenotype affecting CGP 78608 hydrochloride

Human Disease Model