tacrolimus (anhydrous)

Term ID

CHEBI:61049

Synonyms

• (-)-FK 506
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19
• 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
• FK 506
• FK506
• Prograf
• Tacrolimus
• tacrolimus anhydrous

Definition

A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.

References

• CAS:104987-11-3
• DrugBank:DB00864
• KEGG:C01375
• KEGG:D08556
• LIPID_MAPS_instance:LMPK04000003
• PDBeChem:FK5
• Patent:EP184162
• Patent:US5665727
• Reaxys:3647477
• Reaxys:8821611

Ontology

ChEBI  ( EBI )