N-Ac-Asp-N(6)-lipoyl-KATIGFEVQEE

Term ID

CHEBI:60738

Synonyms

lipoated PDC-E2 173-184 peptide
N-Ac-Asp-N(6)-{(R)-lipoyl}-KATIGFEVQEE
N-Ac-Asp-N(6)-{5-[(3R)-1,2-dithiolan-3-yl]pentanoyl}-Lys-Ala-Thr-Ile-Gly-Phe-Glu-Val-Gln-Glu-Glu
N-acetyl-L-alpha-aspartyl-N(6)-{5-[(3R)-1,2-dithiolan-3-yl]pentanoyl}-L-lysyl-L-alanyl-L-threonyl-L-isoleucylglycyl-L-phenylalanyl-L-alpha-glutamyl-L-valyl-L-glutaminyl-L-alpha-glutamyl-L-glutamic acid

Definition

A polypeptide comprising the 12-amino acid sequence KATIGFEVQEE where the N-terminal lysyl (K) residue has an acetyl group at the Nalpha-position and a lipoyl group on the side-chain. A component of the inner lipoyl domain of the second enzyme of the pyruvate dehydrogenase complex (PDC-E2), to which antibodies are raised in the autoimmune disease primary biliary cirrhosis.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: lipopeptide N(alpha)-acetylpeptide polypeptide

lipopeptide N(alpha)-acetylpeptide polypeptide Show first 5 Terms
has_role: epitope

epitope Show first 5 Terms

Phenotype

Phenotype resulting from N-Ac-Asp-N(6)-lipoyl-KATIGFEVQEE

Phenotype where environments contain N-Ac-Asp-N(6)-lipoyl-KATIGFEVQEE

Phenotype modified by environments containing N-Ac-Asp-N(6)-lipoyl-KATIGFEVQEE

Human Disease Model