histrelin

Term ID

CHEBI:5739

Synonyms

• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N(tau)-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• [(im-Bzl)-D-His(6),Pro(9)-NEt]-gonadotropin releasing hormone
• histrelin
• histrelina
• histreline
• histrelinum
• L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-N(im)-benzyl-histidyl-L-leucyl-L-arginyl-L-proline ethylamide
• ORF 17070
• RWJ 17070

Definition

An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

References

• CAS:76712-82-8
• Drug_Central:2975
• KEGG:C07671
• KEGG:D02369
• PMID:19920916
• PMID:19956699
• PMID:20329807
• PMID:21851539
• Patent:US4244946
• Reaxys:4290557
• Wikipedia:Histrelin

Ontology

ChEBI  ( EBI )

Resources

CTD