fludrocortisone acetate

Term ID

CHEBI:5102

Synonyms

• (11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
• 9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
• 9alpha-fluorohydrocortisone 21-acetate
• 9alpha-fluorohydrocortisone acetate
• Alflorone
• Alflorone acetate
• Cortef-F
• Cortineff
• F-Cortef
• F-Cortef acetate
• Florinef
• Florinef acetate
• fludrocortisone 21-acetate
• fluohydrocortisone acetate
• fluorocortisone acetate
• Scherofluron
• U 4845

Definition

An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.

References

• CAS:514-36-3
• Drug_Central:1191
• KEGG:C08186
• KEGG:D00986
• PMID:13271122
• PMID:13361498
• PMID:18193551
• PMID:24316163
• PMID:3197346
• PMID:438959
• PMID:8164382
• PMID:8248344
• Patent:US2957013
• Reaxys:3019450

Ontology

ChEBI  ( EBI )

Resources

CTD