brexanolone

Term ID

CHEBI:50169

Synonyms

• (3alpha,5alpha)-3-hydroxypregnan-20-one
• 3alpha,5alpha-tetrahydroprogesterone
• 3alpha,5alpha-THP
• 3alpha-hydroxy-5alpha-dihydroprogesterone
• 3alpha-hydroxy-5alpha-pregnan-20-one
• 3alpha-OH DHP
• 5alpha-pregnan-3alpha-ol-20-one
• allopregnan-3alpha-ol-20-one
• allopregnanolone
• allotetrahydroprogesterone
• brexanolona
• brexanolone
• brexanolonum
• SAGE-547
• SGE-102
• Zulresso

Definition

A 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women.

References

• Beilstein:3211363
• CAS:516-54-1
• DrugBank:DB11859
• FooDB:FDB022630
• HMDB:HMDB0001449
• KEGG:C13712
• KEGG:D11149
• LINCS:LSM-19998
• LIPID_MAPS_instance:LMST02030130
• PMID:10625505
• PMID:11739473
• PMID:19290593
• PMID:28370307
• PMID:28619476
• PMID:28666923
• PMID:28779545
• PMID:29453777
• PMID:29636114
• PMID:30177236
• PMID:30362283
• PMID:30481569
• PMID:30701996
• PMID:9501247
• Wikipedia:Allopregnanolone

Ontology

ChEBI  ( EBI )