fumagillin

Term ID

CHEBI:48635

Synonyms

(2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoic acid
2,4,6,8-decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester
Fugillin
fumagilina
Fumagillin
fumagilline
fumagillinum
Fumidil

Definition

A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.

References

CAS:23110-15-8
DrugBank:DB02640
Drug_Central:3253
KEGG:C09668
KNApSAcK:C00003133
LIPID_MAPS_instance:LMPR0103060003
PMID:14514693
PMID:14809278
PMID:15723631
PMID:23121865
PMID:23488861
PMID:23505365
Patent:US2652356
Patent:US2803586
Reaxys:5360220
Wikipedia:Fumagillin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: antibiotic antifungal drug carboxylic ester dicarboxylic acid monoester meroterpenoid organooxygen heterocyclic antibiotic ... Show All 6 Terms

antibiotic antifungal drug carboxylic ester dicarboxylic acid monoester meroterpenoid organooxygen heterocyclic antibiotic spiro-epoxide Show first 5 Terms
has_functional_parent: (all-E)-deca-2,4,6,8-tetraenedioic acid fumagillol

(all-E)-deca-2,4,6,8-tetraenedioic acid fumagillol Show first 5 Terms
has_role: angiogenesis inhibitor antibacterial drug antimicrobial agent antiprotozoal drug fungal metabolite ... Show All 6 Terms

angiogenesis inhibitor antibacterial drug antimicrobial agent antiprotozoal drug fungal metabolite methionine aminopeptidase 2 inhibitor Show first 5 Terms
inverse is_substituent_group_from: fumagillin-2-yl group

fumagillin-2-yl group Show first 5 Terms

Phenotype

Phenotype resulting from fumagillin

Phenotype where environments contain fumagillin

Phenotype modified by environments containing fumagillin

Human Disease Model