esmolol

Term ID

CHEBI:4856

Synonyms

• (+-)-esmolol
• (+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
• 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester
• esmolol
• esmololum
• Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate
• methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
• rac-methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate

Definition

A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure.

References

• Beilstein:5287174
• CAS:103598-03-4
• CAS:81147-92-4
• DrugBank:DB00187
• HMDB:HMDB0014333
• KEGG:C06980
• KEGG:D07916
• PMID:16118074
• PMID:24500140
• PMID:25105423
• PMID:25575405
• PMID:26073350
• PMID:26137757
• PMID:26316443
• Patent:EP41491
• Patent:EP53435
• Patent:US4593119
• Reaxys:5287174
• Wikipedia:Esmolol

Ontology

ChEBI  ( EBI )