dimenhydrinate

Term ID

CHEBI:4604

Synonyms

• (O-benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate
• 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide
• 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
• Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline
• beta-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine
• dimenhidrinato
• dimenhydrinate
• dimenhydrinatum
• diphenhydramine 8-chlorotheophyllinate
• diphenhydramine 8-chlorotheophylline
• diphenhydramine theoclate
• N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate
• O-benzhydryldimethylaminoethanol 8-chlorotheophyllinate

Definition

The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention and treatment of motion sickness.

References

• CAS:523-87-5
• DrugBank:DB00985
• KEGG:D00520
• Patent:US2499058
• Patent:US2534813

Ontology

ChEBI  ( EBI )

Resources

CTD