suramin

Term ID

CHEBI:45906

Synonyms

• 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID
• 8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid
• Belganyl
• Naganol
• Naphuride
• Suramin

Definition

A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

References

• AGR:IND606744035
• Beilstein:3230873
• Beilstein:8185304
• CAS:145-63-1
• Chemspider:5168
• DrugBank:DB04786
• Drug_Central:2966
• HMDB:HMDB0015582
• KEGG:C07974
• LINCS:LSM-5775
• PDBeChem:SVR
• PMID:11549724
• PMID:15733555
• PMID:15774519
• PMID:28457855
• PMID:29414872
• PMID:30172846
• PMID:30393012
• PMID:30449075
• PMID:30528604
• PMID:30543088
• PMID:30771091
• PMID:31346035
• PMID:31409229
• PMID:31667504
• PMID:31727005
• PMID:31803569
• PMID:31844000
• PMID:7947391
• PMID:8769855
• Wikipedia:Suramin

Ontology

ChEBI  ( EBI )

Resources

CTD