digoxin

Term ID

CHEBI:4551

Synonyms

(3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
12beta-hydroxydigitoxin
digoxin

Definition

A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.

References

Beilstein:77011
CAS:20830-75-5
DrugBank:DB00390
Drug_Central:882
KEGG:C06956
KEGG:D00298
KNApSAcK:C00003618
PDB:1IGJ
PDBeChem:DGX
PMID:10438974
PMID:16970134
PMID:7739045
PMID:8234291
Reaxys:77011
Wikipedia:Digoxin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: cardenolide glycoside steroid saponin

cardenolide glycoside steroid saponin Show first 5 Terms
has_role: anti-arrhythmia drug cardiotonic drug EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor epitope

anti-arrhythmia drug cardiotonic drug EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor epitope Show first 5 Terms
inverse has_functional_parent: 12-O-acetyldigoxin 20,22-dihydrodigoxin

12-O-acetyldigoxin 20,22-dihydrodigoxin Show first 5 Terms
inverse is_conjugate_base_of: digoxin(1-)

digoxin(1-) Show first 5 Terms
is_conjugate_acid_of: digoxin(1-)

digoxin(1-) Show first 5 Terms

Phenotype

Phenotype resulting from digoxin

Phenotype where environments contain digoxin

Phenotype modified by environments containing digoxin

Human Disease Model