Search Ontology:
ChEBI
ritonavir
- Term ID
- CHEBI:45409
- Synonyms
-
- N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
- ritonavir
- Definition
- An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
- References
-
- CAS:155213-67-5
- Drug_Central:2391
- HMDB:HMDB0014646
- KEGG:C07240
- KEGG:D00427
- LINCS:LSM-5623
- PDBeChem:RIT
- PMID:11363086
- PMID:11363184
- PMID:11363300
- PMID:11363329
- PMID:11363397
- PMID:11363517
- PMID:11996889
- PMID:24202050
- PMID:38578027
- PMID:38609668
- PMID:8568292
- PMID:9140265
- PMID:9278209
- PMID:9585800
- Reaxys:768009
- Wikipedia:Ritonavir
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
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- inverse has_part
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Phenotype
Phenotype resulting from ritonavir
Phenotype where environments contain ritonavir
Phenotype modified by environments containing ritonavir
Human Disease / Model Data