(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Term ID

CHEBI:45302

Synonyms

(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione
5-[(quinoxalin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
5-quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione
AS 605240
AS-605240
AS605240

Definition

A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: quinoxaline derivative thiazolidinediones

quinoxaline derivative thiazolidinediones Show first 5 Terms
has_role: anti-inflammatory agent antirheumatic drug EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor

anti-inflammatory agent antirheumatic drug EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Phenotype where environments contain (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Phenotype modified by environments containing (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Human Disease Model