okadaic acid

Term ID

CHEBI:44658

Synonyms

• (2R)-2-hydroxy-3-{(2S,5R,6R,8S)-5-hydroxy-8-[(2R,3E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-e
• 9,10-Deepithio-9,10-didehydroacanthifolicin
• Okadaic acid

Definition

A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.

References

• Beilstein:4640246
• Beilstein:4900372
• Beilstein:5471989
• CAS:78111-17-8
• DrugBank:DB02169
• KEGG:C01945
• PDBeChem:OKA
• PMID:28429183
• PMID:28476539
• PMID:28648727
• PMID:28755633
• PMID:28817087
• Reaxys:4640246

Ontology

ChEBI  ( EBI )

Resources

CTD