Ac-(D)Phe-Pro-boroArg-OH

Term ID

CHEBI:42142

Synonyms

acetylphenylalanyl-prolyl-boroarginine
N-acetyl-D-phenylalanyl-N-[(1R)-1-borono-4-carbamimidamidobutyl]-L-prolinamide

Definition

A C-terminal boronic acid petide that is N-acetyl-D-phenylalanyl-L-prolyl-L-arginine in which the C-termnal carboxy group has been replaced by a borono (-B(OH)2) group. A thrombin (Factor IIa) inhibitor, thereby acting as an anticoagulant.

References

CAS:130982-43-3
PDBeChem:DP7
Reaxys:24287151

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: acetamides C-terminal boronic acid peptide guanidines

acetamides C-terminal boronic acid peptide guanidines Show first 5 Terms
has_role: anticoagulant EC 3.4.21.5 (thrombin) inhibitor

anticoagulant EC 3.4.21.5 (thrombin) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: Ac-(D)Phe-Pro-boroArg-OH(1+)

Ac-(D)Phe-Pro-boroArg-OH(1+) Show first 5 Terms
is_conjugate_base_of: Ac-(D)Phe-Pro-boroArg-OH(1+)

Ac-(D)Phe-Pro-boroArg-OH(1+) Show first 5 Terms

Phenotype

Phenotype resulting from Ac-(D)Phe-Pro-boroArg-OH

Phenotype where environments contain Ac-(D)Phe-Pro-boroArg-OH

Phenotype modified by environments containing Ac-(D)Phe-Pro-boroArg-OH

Human Disease / Model Data