Search Ontology:
ChEBI
AEE788
- Term ID
- CHEBI:40629
- Synonyms
-
- 6-{4-[(4-ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine
- 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- [6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-((R)-1-phenylethyl)amine
- AEE 788
- AEE-788
- NVP-AEE-788
- NVP-AEE788
- Definition
- A 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which adopts an R-configuration. It is a potent inhibitor of human EGFR, VEGFR and HER2 receptor tyrosine kinases and exhibits anticancer and antiangiogenic activity.
- References
-
- CAS:497839-62-0
- Chemspider:8472511
- DrugBank:DB12558
- LINCS:LSM-45507
- PDBeChem:AEE
- PMID:15256466
- PMID:15520205
- PMID:15756022
- PMID:15827337
- PMID:16740767
- PMID:16926628
- PMID:17317822
- PMID:17349580
- PMID:17876047
- PMID:18227510
- PMID:18337021
- PMID:18688594
- PMID:18813786
- PMID:19473483
- PMID:19594733
- PMID:19945288
- PMID:20090347
- PMID:20148349
- PMID:20380868
- PMID:20386540
- PMID:20647329
- PMID:20878094
- PMID:20885895
- PMID:20954195
- PMID:21984222
- PMID:22392572
- PMID:22922496
- PMID:23014528
- PMID:24468788
- PMID:26107817
- PMID:28246189
- PMID:30705084
- PMID:31388935
- Wikipedia:AEE788
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
Phenotype
Phenotype resulting from AEE788
Phenotype where environments contain AEE788
Phenotype modified by environments containing AEE788
Human Disease / Model Data