EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Term ID

CHEBI:35664

Synonyms

HMG-CoA reductase inhibitor
HMG-CoA reductase inhibitors
hydroxymethylglutaryl-CoA reductase inhibitor
hydroxymethylglutaryl-CoA reductase inhibitors

Definition

Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor

EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor Show first 5 Terms
inverse has_role: 3,3,5-trimethylcyclohexanol 3-hydroxy-3-methylglutaric acid compactin diol lactone mevinic acid mevinolinic acid ... Show All 10 Terms

3,3,5-trimethylcyclohexanol 3-hydroxy-3-methylglutaric acid compactin diol lactone mevinic acid mevinolinic acid ML-236C monacolin J monacolin L simvastatin statin Show first 5 Terms

Phenotype

Phenotype resulting from EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Phenotype where environments contain EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Phenotype modified by environments containing EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Human Disease Model