mevastatin

Term ID

CHEBI:34848

Synonyms

• (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• antibiotic ML 236B
• Compactin
• CS 500
• Mevastatin
• mevastatina
• mevastatine
• mevastatinum
• ML 236 B
• ML-236B

Definition

A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.

References

• CAS:73573-88-3
• DrugBank:DB06693
• KEGG:C13963
• KNApSAcK:C00000564
• LINCS:LSM-4123
• PMID:11283400
• PMID:12403272
• PMID:15274361
• PMID:15531285
• PMID:15786722
• PMID:18672387
• PMID:18936176
• PMID:20629200
• PMID:23918904
• PMID:24462564
• PMID:3170348
• PMID:3719857
• Patent:DE2524355
• Patent:US3983140
• Reaxys:3630717
• Wikipedia:Mevastatin

Ontology

ChEBI  ( EBI )